What is an idiosyncratic drug reaction?
Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by the known mechanisms of action of the offending agent, do not occur at any dose in most patients, and develop mostly unpredictably in susceptible individuals only.
What are examples of idiosyncratic?
An example of an idiosyncratic person is someone who does a lot of out of the ordinary things. An example of an idiosyncratic trait is the way a person always deals with disappointment. An example of an idiosyncratic reaction to a drug is the unique way that someone reacts to a medication.
When would you see an idiosyncratic response?
Idiosyncratic DILI typically occurs 13 months after initiation of a drug but varies among drugs and patients. This latency between initiation of therapy and the onset of liver disease is a component of the signature of reactions to specific drugs and provides some clues to the pathogenesis.
What is an example of an adverse drug reaction?
Examples of such adverse drug reactions include rashes, jaundice, anemia, a decrease in the white blood cell count, kidney damage, and nerve injury that may impair vision or hearing. These reactions tend to be more serious but typically occur in a very small number of people.
What is an idiosyncratic type?
If you describe someone’s actions or characteristics as idiosyncratic, you mean that they are rather unusual. […]
What is idiosyncratic toxicity?
Idiosyncratic toxicity can occur when a convergence of risk factors, including drug exposure, tips the risk-benefit balance away from benefit and toward risk.
Which is the best example of idiosyncratic risk?
Example of idiosyncratic risk For example, the changes in the tax policy, inflation, customer demands, and interest rates are some of the factors that affect the company’s stock price but have nothing to do with its managerial skills. Most importantly, it isn’t something the company can control or avoid.
What is a idiosyncratic in medical terms?
Idiosyncrasy is an abnormal reactivity to a chemical that is peculiar to a given individual. It could be: An abnormally exaggerated response, or an abnormal lack of response. A response unusual because it requires an unusually small or unusually large dose. An extension of the normal physiological drug effect.
Which of the following is an example of idiosyncratic risk?
In terms of industry or sector, an example of idiosyncratic risk for mining companies would be the exhaustion or the inaccessibility of a vein or a seam of metal. Likewise, the possibility of a pilots’ or a mechanics’ strike would be an idiosyncratic risk for airline companies.
What are symptoms of an idiosyncratic reaction to contrast media?
These reactions primarily include fevers, chills, rigors, flushing, dizziness, and, occasionally, hypotension. These reactions can occur even if immunotherapy is administered as long as 2 years before ICM administration.
What is metabolic idiosyncrasy?
Drugs that cause IDILI with evidence of an immune response, such as halothane, are classed as immune idiosyncrasy, whereas those without obvious signs of an immune response have been classed as metabolic idiosyncrasy (Zimmerman, 1999).
What is drug synergy?
Abstract. Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.
What is the most common adverse drug reaction?
Any drug has the potential to cause an allergic reaction. Symptoms of adverse drug reactions include cough, nausea, vomiting, diarrhea, and headaches. Skin reactions (i.e. rashes, itching) are the most common form of allergic drug reaction.
What is an adverse drug reaction Give 2 3 examples?
Examples of such adverse drug reactions include rashes, jaundice, anemia, a decrease in the white blood cell count, kidney damage, and nerve injury that may impair vision or hearing. These reactions tend to be more serious but typically occur in a very small number of people.
What is an immune mediated reaction?
Abstract. Many adverse drug reactions are mediated by the immune system. This can be because the therapeutic effect of the drug targets the immune system. For example, immunosuppressive drugs increase the risk of infections. It is paradoxical that some immunosuppressive drugs can lead to autoimmune reactions.
What are idiosyncratic beliefs?
Idiosyncratic individuals are tuned in to and sustained by their own feelings and belief systems, whether or not others accept or understand their particular worldview or approach to life. Own world. They are self-directed and independent, requiring few close relationships. Own thing.
What is another word for idiosyncrasy?
In this page you can discover 16 synonyms, antonyms, idiomatic expressions, and related words for idiosyncrasy, like: quirk, peculiarity, eccentricity, characteristic, idiom, habit, affectation, mannerism, quirkiness, idiosyncracy and trait.
Which is an example of a characters distinct or idiosyncratic behavior?
Idiosyncratic: This adjective describes someone or something that has individual or eccentric traits or mannerisms. It can also be used to describe the characteristic, itself, that is peculiar to a person. Example: The way that his shirt refused to be ironed without turning it inside out was rather idiosyncratic.
How does idiosyncratic reaction affect medication actions?
Idiosyncratic drug reactions appear to not be concentration dependent. A minimal amount of drug will cause an immune response, but it is suspected that at a low enough concentration, a drug will be less likely to initiate an immune response. …
| Idiosyncratic drug reaction | |
|---|---|
| Specialty | Emergency medicine |
What is an idiosyncratic person?
Idiosyncratic means unique to an individual. Albert Einstein famously had lots of idiosyncratic habits. … One thing that Einstein definitely wasn’t was an idiot. Yet idiosyncratic and idiot are related. Idio is ancient Greek for one’s own. An idiosyncratic person is someone who does things in his own way.
What is idiosyncrasy and allergy?
An Idiosyncrasy causing symptoms like allergy is also called pseudoanaphylaxis and its presentation is similar to that of anaphylaxis. It however does not involve an allergic reaction but is due to direct mast cell degranulation.
What is idiosyncratic skewness?
Idiosyncratic skewness measure. After excluding all common factors that affect stock returns, the description of the return distribution that deviates from that symmetry caused by other factors is defined as idiosyncratic skewness.
Is beta idiosyncratic risk?
Thus, beta is referred to as an asset’s non-diversifiable risk, its systematic risk, market risk, or hedge ratio. Beta is not a measure of idiosyncratic risk.
What are idiosyncratic shocks?
Idiosyncratic shocks affect only the members of an individual household, as opposed to covariate shocks, which involve entire communities or countries. Shocks are defined here as events that reduce household. income, consumption, and/or the accumulation of productive assets.
What is a medication generic name?
Generic name, drug: The term generic name has several meanings as regards drugs: The chemical name of a drug. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug is sold. A term referring to any drug marketed under its chemical name without advertising.
When is the combined effect of two drugs?
When two drugs are used together, their effects can be additive (the result is what you expect when you add together the effect of each drug taken independently), synergistic (combining the drugs leads to a larger effect than expected), or antagonistic (combining the drugs leads to a smaller effect than expected).
What is idiosyncratic culture?
The word idiosyncrasy is used here to signify peculiarity, or typicality. Culture is an idiosyncratic good because of its essential connection with a given place and a given epoch. Time and space are the basic attributes of idiosyncrasy.
How do you hedge idiosyncratic risk?
The most effective way to mitigate or attempt to eliminate idiosyncratic risk is with the diversification of investments. Idiosyncratic risk, by its very nature, is unpredictable. Studies show that most of the variation in risk that individual stocks face over time is created by idiosyncratic risk.
What is idiosyncratic volatility?
Based on asset-pricing models, idiosyncratic volatility measures the part of the variation in returns that cannot be explained by the particular asset-pricing model used.
Perrine Juillion
Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with Sun’Agri and INRAE in Avignon between 2019 and 2022. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. I love to write and share science related Stuff Here on my Website. I am currently continuing at Sun’Agri as an R&D engineer.